February 12, 2009
Cannon Room, HMS Quad
Speaker: Richard N.
Bergman, PhD
Title: “Systems
Biology and Glucose Homeostasis: Prediction, Prevention and Genetics of Type 2
Diabetes."
Question: How can we use systems biology analysis to explain
principles underlying diabetes, and to predict the disease in at-risk
individuals?
Quantitative Method: Engineering analysis
methods including computer modeling coupled with statistical genetics and genome-wide
association studies.
Medical Impact: This work has led to
explaining the importance of insulin resistance versus impaired insulin
secretory function in the pathogenesis of Type 2 diabetes. It has allowed for
the development of methods most powerful for predicting Type 2 diabetes, and
for assessing the effects of therapies on the progression of disease. It has
generated a quantitative parameter most aligned with genetic signals associated
with increased risk for Type 2 diabetes.
Speaker URL: http://www.usc.edu/programs/pibbs/site/faculty/bergman_r.htm
Suggested
Rich
S.S. and R.N. Bergman. The genetic basis of glucose homeostasis. Curr. Diab.
Rev. 1:221-226, 2005.