February 12, 2009
Cannon Room, HMS Quad
Speaker: Richard N. Bergman, PhD
Title: “Systems Biology and Glucose Homeostasis: Prediction, Prevention and Genetics of Type 2 Diabetes."
Question: How can we use systems biology analysis to explain principles underlying diabetes, and to predict the disease in at-risk individuals?
Quantitative Method: Engineering analysis methods including computer modeling coupled with statistical genetics and genome-wide association studies.
Medical Impact: This work has led to explaining the importance of insulin resistance versus impaired insulin secretory function in the pathogenesis of Type 2 diabetes. It has allowed for the development of methods most powerful for predicting Type 2 diabetes, and for assessing the effects of therapies on the progression of disease. It has generated a quantitative parameter most aligned with genetic signals associated with increased risk for Type 2 diabetes.