November 13, 2008

4-6 PM

Cannon Room, HMS Quad



Speaker:                                 William F. Crowley, M.D.


Title:                                        “The Importance of Pulsatile Secretion; Examples from Endocrinology”


Question:                                 Why are some hormones released in a pulsatile manner?


Quantitative Method:              Quantitative human physiology and pathophysiology


Medical Impact:                      Reproductive physiology, pathophysiology, and therapeutics


Speaker URL:               


Suggested Reading:               Nachtigall LB, Boepple PA, Pralong FP, Crowley WF.  Adult-onset idiopathic hypogonadotropic hypogonadism:  A new treatable form of male infertility. N Engl J Med. 1997; 336:410-15.


                                                Weiss J, Harris PE, Halvorson LM, Crowley WF, Jameson JL.  Dynamic regulation of follicle-stimulating hormone-b messenger ribonucleic acid levels by activin and gonadotropin-releasing hormone in perifused rat pituitary cells.  Endocrinol 1992; 131:1403-08.


                                                Conn PM, Crowley WF. Gonadotropin-releasing hormone and its analogues. N Engl J Med  1991; 324:93-103.


                                                Weiss J, Jameson JL, Burrin JM, Crowley WF.  Divergent responses of gonadotropin subunit messenger RNAs to continuous versus pulsatile gonadotropin-releasing hormone in vitro. Molecular Endocrinol 1990; 4:557-64.


                                                Santoro N, Filicori M, Crowley WF.  Hypogonadotropic disorders in men and women: diagnosis and therapy with pulsatile gonadotropin-releasing hormone.  Endocrine Reviews 1986; 7:11-23.


                                                Hoffman AR, Crowley WF.  Induction of puberty in men by long-term pulsatile administration of low-dose gonadotropin-releasing hormone.  N Engl J Med 1982; 307:1237-41.


                                                Comite F, Cutler GB, Rivier J, Vale WW, Loriaux DL, Crowley WF.  Short-term treatment of idiopathic precocious puberty with a long-acting analogue of luteinizing hormone-releasing hormone.  A preliminary report.  N Engl J Med 1981; 305:1546-50.