Cannon Room, HMS Quad
Speaker: Jeffrey Fredberg, PhD
Title: “Frozen objects: small airways, big breaths, and asthma.”
Question: How does stretch influence sub-cellular mechanical properties?
Quantitative Method: Molecular-scale experimental probes of cytoskeletal deformability, contractility, and remodeling.
Medical Impact: During the asthmatic attack, airway smooth muscle undergoes a phase transition and becomes frozen in a stiff glassy state.
Fredberg, JJ. Frozen objects: small airways, big breaths and asthma. J. of Allergy and Clinical Immunology (2000), 106, 615-24.